Medicinal extract.



FFTC,

LUDWIG BAUER, or NIEDERLOSSNITZ, GERMANY.

MEDICINAL EXTRACT.

Specification of Letters Patent.

Patented March 12, 1907.

Application filed December 8, 1904; Serial No. 235,970.

To all whom it may concern.-

Be it known that I, LUDWIG BAUER, physiolo ical chemist, a citizen of the Kingdom of axony, and a resident of Niederlossnitz, whose post-oflice address is No. 3 Grenzstrasse, Kotzschenbroda, in the Kingdom of Saxony, Germany, have invented certain new'and useful Improvements in Medicinal Extracts, of which the following is aspecification.

This invention relates to a medicine for treating diabetes.

It further relates to a process for obtaining said medicine by extracting a mixture of the The process is carried out in the following manner: 'Five thousand grams of dried see and bark of Eugenia ja'mbolana and five thousand grams of dried cola-nuts are mixed and ground as finely as possible; 'One hundred and twenty-five grams of lime and two thousand five hundred grams of water are then added to said mixture and the whole is triturated to pulp under the influence of gentle heat and then allowed to stand for about twent -four hours. During this time a considera le quantity of ammonia and readilyvolatile amin bases are evolvedl' After this the mass is stirred with warm water and is saturated with carbon dioxid until the alkalinity amounts to only from two to three per cent. The whole is then exhaustively extracted in an extractor with ten thousand grams of water heated to about 50 centigrade, the weak alkalinity increasing considerably the dissolving power. After extraction the liquid is concentrated and is filtered through freshly-reheated animal charcoal. In order to improve the flavor, an suitable tinctures may be added to the fil trate.

The fluid extract produced by my invenfrom t tion has a bitter taste, a specific gravity of approximately 1.020", and reduces Fehlings solution.

For want of sufiiciently successful progress in the very diflicult examination of the product the nature of the effective substances obtained according to the present process from the above-mentioned drugs must for the present remain undecided. The essence of the subject-matter of the present application is distinguished in principle e well-known processes for obtaining caffein or the lucosid colanine from cola-nuts, as wel as from the method for obtaining antimellin according to German Patent 119,864 or from the hitherto employed method of producing extracts from the above-mentioned drugs.

Of the separate steps of the present process it is true that some are well-known in their application to drugs partly for analytical and partly for technical purposes. Thus, among others, workin prescriptions for lixiviating by means of alkaline liquids are well known. The determination of caffein in drugs (tea, cola) is carried out, for example, by mixing ondigesting the dried powder of the drug in question with slaked lime and then extracting it with water, ether, chloroform, &c. Moreover, it is well known that alkalies-among others, lime-have a decomposing action on many alkaloids, and lime has also, in addition, the property of forming insoluble or diflicultly soluble comounds with other vegetable matter and of avin in this manner a purifying action, (as. regards the obtaining of caflein.) The treatment of extracts (for the purpose of decolorizing the same) with charcoal is also an operation which is often employed and has long been known. Further, the treatment of organic-lime compounds with carbon dioxid for the purpose of precipitating calcium carbonate is also a well-known working process. These are substantially the older methods of treating similar drugs employed in the present process, it being their object, on the one hand, to obtain pure caifein and, on the other hand, to produce an aqueous extract of unknown composition.

The present invention has the important distinction, in comparison with the processes mentioned above, as well known, that the agents or materials which are effective against diabetes are obtained from dried cola-nuts and from the dried seed or bark of Eu emla jambolanaby treating these materia s in a definite systematic succession of erations as follows: first, with lime under t e influence of slight-heat second, with carbon dioxid for converting the lime into carbonate and decomposing a part of the calcium salt and double compounds down to a definite alkalinity; third, extracting the pulp with water at about 50centigrade; fourth, filtering through animal charcoal for the purpose oi removing the precipitated calcium carbonate and the insoluble organically-acidcalcium salt still present, as well as for the purpose of decolorizing the extract.

By means of'the present methodof working,in contrast with the well-known se arate processes a special new unexpected e ect is obtained, I namely, hitherto it had been desired to obtain the vegetable alkaloids from the drugs not in the free condition, which ac cording to previous 0 inions is less effective,

but inthe form of the g ucosid orother readily-. 5

deco'mposible compounds, a V preliminary treatment of the drugs with alkali or bases of the alkaline earths would have been out of the question, as the glucosid are hereby de-- composed,.and on being treated with'the application of heat the -k1nd of sugar liberated 1s completely destroyed or caramelized. It would therefore have been necessary in this case to use a solvent other than waterfor example, ether-chloroform or alcohol, &c. As, however, these solvents also carry into solution many other organic materials in the drugs, a subsequent liberation of the latter .without destroying glucosid takes place with considerably. greater difliculty than in the case of the primary treatment with lime. By means of-my process this undesirable destructive' eflect of the alkaline earth is prevented,

. and solely its partial disintegrating property,

with respect to the dru s, is turned to useful account. An action 0 excess quicklime in the presence of heat on the chemical compcnmds contained in the drugs 'is avoided. The purification of the extract is performed by means of animalcharcoal, which serves centrating chiefly to separate the calcium salt still pres ent in the extract. That the desired effect is obtained" by the rocess described is shown with Fehlings solution shows a strong power of reduction, from which pro erty the i bythe fact that t e extract, when inverted,

presence of glucosid maybe conc uded, al-

though success has not attended attempts to isolate the various substances, and consequently their chemical nature has not been more definitely ascertained.

Having thus described my invention, what I claim' as new, and desire to secure by Letters Patent, is v 1. The hereindescribed process, which consists in subjecting a mixture of cola-nuts and seeds and bark of Eugenia y'ambolana to the action of milk of lime, agitating such drugs with the admixture of water, saturating the mixture with carbon dioxid,.dilutin with water, and filtering through animal charcoal.

'2. The herein-described oces's, which consists in subjecting a mixture of cola-nutsand seeds and bark of Eugenia jambolcma to the action of milk of lime, agitating such-i;

drugs with the admixture of water, saturat ing the mixture with carbon dioxid to reduce the alkalinity to approximately 0.2 per cent,

diluting with water at substantially 50 6613- tigrade, and filtering through animal charcoal.

3. The herein-described process, which consists in reducing a mixture of cola-nuts and seeds and bark of Eugenia ja'mbo to a \fine powder,'t'riturating such powder with PAUL ARRAs. 

